History:

Acetylsalicylic Acid (Aspirin) History
Here's a brief overview of the history of acetylsalicylic acid, also known as aspirin ¹:

  • 1897: Scientists at Bayer started investigating acetylated compounds as potential medicines.
  • 1899: Bayer synthesized acetylsalicylic acid (ASA) and marketed it worldwide as "Aspirin."
  • 1899-1900: Production of Aspirin began, and Bayer distributed it to doctors, pharmacists, and hospitals.
  • 1900: Aspirin was patented in the United States (US Patent 644,077).
  • 1914-1918: During World War I, Bayer faced competition and challenges in maintaining Aspirin production.
  • 1915: The Great Phenol Plot was uncovered, which involved German agents orchestrating a scheme to secure phenol for Aspirin production.
  • 1917: The U.S. declared war on Germany, and Bayer's American assets were seized.
  • 1918: The Spanish flu pandemic began, and Aspirin became a highly sought-after drug.
  • 1920: The U.S. ASA patent expired, and the "Aspirin" trademark became generic for public sale in the U.S.
  • 1994: Bayer AG repurchased the rights to Bayer Aspirin and the U.S. rights to the Bayer name and trademarks for $1 billion.

Acetylsalicylic Acid use:


Acetylsalicylic acid, also known as aspirin, is used for the treatment of 
  • Pain relief for mild to moderate pain, swelling, and other health issues.
  • Reducing fever.
  • Lowering inflammation.
  • Relieving pain and swelling associated with health issues, such as headaches, sprains, arthritis and migraines.
  • Treating coronary events, such as heart attack, stroke, or cardiovascular event to prevent further blood clots.
  • Preventing blood clots stroke and myocardial infarction.
  • Preventing thromboembolism after hip replacement surgery.
  • Reducing platelet to platelet adhesion following carotid endarterectomy, aiding in the prevention of transient ischemic attacks.

Acetylsalicylic Acid (Aspirin) Side Effects:

Common side effects of acetylsalicylic acid (aspirin) include:
  1. Gastrointestinal:
    • Nausea
    • Vomiting
    • Abdominal pain
    • Heartburn
    • Ulcers
  2. Allergic Reactions:
    • Hives
    • Itching
    • Swelling
    • Difficulty breathing
  3. Bleeding:
    • Easy bruising
    • Pink or brown urine
    • Bloody stools
  4. Kidney:
    • Kidney failure (long-term use or high doses)
  5. Liver:
    • Elevated liver enzymes
  6. Hearing:
    • Ringing in the ears (tinnitus)
  7. Other:
    • Dizziness
    • Headaches
    • Fatigue
    • Confusion
Serious Side Effects (rare):
  1. Stomach Ulcer Bleeding
  2. Kidney Failure
  3. Liver Damage
  4. Severe Allergic Reactions
  5. Hearing Loss
Long-term Use:
  1. Gastrointestinal Ulcers
  2. Kidney Damage
  3. Hearing Loss
If you experience any side effects or have concerns, consult your healthcare provider.