Cyclizine  History

Cyclizine is an antihistamine medication with a rich history dating back to the 1950s. Here's a brief overview:
  • 1953: Cyclizine was first synthesized by British scientists at the pharmaceutical company, Wellcome (now part of GlaxoSmithKline).
  • 1955: Cyclizine was introduced as a treatment for motion sickness, vertigo, and nausea under the brand name "Marzine".
  • 1960s: Cyclizine became widely used for its anti-emetic properties, particularly in the treatment of chemotherapy-induced nausea and vomiting.
  • 1980s: The medication's use expanded to include the treatment of migraines, anxiety, and insomnia.
  • 1990s: Cyclizine's popularity waned with the introduction of newer, more targeted medications, such as ondansetron and granisetron.
  • Present day: Cyclizine remains in use, primarily for motion sickness, vertigo, and nausea, although its use is generally limited due to its potential for adverse effects and the availability of more effective and safer alternatives.
Throughout its history, cyclizine has been marketed under various brand names, including Marzine, Marezine, and Valoid. Despite its reduced usage, cyclizine remains an important part of the history of antihistamine development and the treatment of nausea and vomiting.



Cyclizine: Uses in Treatment
Cyclizine is an antihistamine medication used to treat various conditions, including:
  1. Motion Sickness: Cyclizine is effective in preventing and treating motion sickness, including seasickness, carsickness, and airsickness.
  2. Vertigo: It helps alleviate symptoms of vertigo, such as dizziness and nausea.
  3. Nausea and Vomiting: Cyclizine is used to treat nausea and vomiting caused by various factors, including chemotherapy, radiation therapy, and viral infections.
  4. Migraines: It has been used to treat migraines, although its effectiveness for this condition is debated.
  5. Anxiety and Insomnia: Cyclizine has been used as an anxiolytic and hypnotic due to its sedative properties.
  6. Gastrointestinal Issues: It may be used to treat gastrointestinal conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
Important:
  • Cyclizine should only be used under medical supervision, especially in children, pregnant women, and individuals with certain medical conditions.
  • It's essential to follow the recommended dosage and duration of treatment to minimize the risk of adverse effects.
Please consult a healthcare professional for personalized advice and treatment.

Cyclizine: Side Effects
Cyclizine can cause various side effects, including:
Common Side Effects:
  1. Drowsiness
  2. Dry mouth
  3. Dizziness
  4. Headache
  5. Fatigue
  6. Blurred vision
  7. Nausea
  8. Vomiting
  9. Constipation
  10. Increased appetite
Less Common Side Effects:
  1. Confusion
  2. Disorientation
  3. Hallucinations (rarely)
  4. Seizures (rarely)
  5. Allergic reactions (such as rash, itching, and swelling)
  6. Blood disorders (such as agranulocytosis and thrombocytopenia)
  7. Liver damage (rarely)
  8. Muscle weakness
  9. Tremors
  10. Palpitations
Important:
  • If you experience any side effects, consult your doctor or pharmacist.
  • Cyclizine can interact with other medications, so inform your doctor about all medications you're taking.
  • In rare cases, cyclizine can cause serious side effects. Seek immediate medical attention if you experience any unusual symptoms.
Please consult a healthcare professional for personalized advice and treatment.